TESTOLONE RAD140 Powder

RAD-140 Powder SARM Romania

RAD-140, also known as Testolone, belongs to a class of nonsteroidal selective androgen receptor modulators (SARMs). These substances bind to the androgen receptor, which is the principal action of testosterone, showing high affinity for muscle tissue and bone tissue. Unlike anabolic androgenic steroids or anabolic steroids, it was designed as a potential alternative form of androgen therapy.

RAD-140 (Testolone) was initially characterized and discovered in the United States. A 2011 study led by researchers at the University of Illinois at Urbana–Champaign and Cambridge Major Laboratories in Wisconsin described its design as an orally bioavailable, nonsteroidal SARM in preclinical models.

Radius Health developed RAD-140 to prevent muscle and bone density loss caused by conditions such as cancer cachexia; later clinical interest has included hormone-receptor cancers (for example, AR+/ER+ breast cancer). Furthermore, as a SARM, it binds to specific ARs (androgen receptors) in the body, particularly in skeletal and muscle tissues. Another advantage of RAD-140 is that it is non-steroidal and is not converted to DHT (dihydrotestosterone); preclinical studies also show markedly reduced stimulation of receptors in the seminal vesicles and prostate compared with testosterone.

Romania Preclinical studies in animal models demonstrated that this compound increases muscular growth, stimulates the levator ani muscle, improves lean body mass, and shows strong anabolic activity. Findings highlight its important role in regulating testosterone levels, but it remains intended strictly for research use.

Benefits of RAD-140 Powder SARM Romania

Weight Loss

The compound has been linked to possible weight loss benefits because of its capacity to increase lean muscle mass and metabolic activity. It can promote muscular growth, which may lead to higher energy use and fat reduction. Its anabolic properties may also increase strength and exercise performance, allowing for more effective calorie-burning.

Increased Muscle Mass

This SARM has shown significant potential for increasing muscle mass and muscle strength. By targeting androgen receptors in muscle tissues, it promotes protein synthesis and growth while avoiding many side effects seen with steroids or dietary supplements. According to current knowledge, it may improve body weight, muscle weight, and performance in healthy adults, though the safety of SARMs is still under review.

Neurodegenerative Diseases Treatment

Romania Research suggests the compound may have neuroprotective properties by lowering cell death caused by toxic factors. Such effects point to an important role in studies of different tissues, including brain health. Preclinical findings encourage further systematic review and ongoing clinical trials, though its effects in healthy adults remain unproven.

Breast Cancer Prevention

This SARM has also been studied in estrogen receptor and androgen receptor-positive breast cancer models, particularly in postmenopausal women. These AR+/ER+ breast-cancer subtypes are especially common in postmenopausal women, and RAD-140 has shown activity in AR+/ER+ preclinical models and early-phase clinical trials targeting this disease. By functioning as a selective AR agonist, it presents a unique approach in cancer cachexia and hormone-related cancers. Romania Studies highlight the effects of SARMs on bone tissue and cancer biology, but more trials are required.

What Do Researchers Say About RAD-140 Safety and Approval?

Like other SARMs, research has reported adverse events and adverse effects. Some case reports link the compound to acute liver failure, liver disease, and changes in testosterone production. These findings highlight the need for more controlled studies. They are needed to fully understand potential risks across different groups and conditions.

The effects of SARMs vary across different tissues. More systematic reviews and ongoing clinical trials are needed to evaluate their overall safety profile.

From a regulatory standpoint, the World Anti-Doping Agency (WADA) prohibits the use of SARMs in competitive sports. This is due to their strong anabolic effects and potential performance enhancement. This compound is classified as a research chemical. It is not approved by the FDA or the US Food and Drug Administration for human use. Despite its strong anabolic activity, it remains restricted to laboratory settings and controlled drug administration studies.

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References:

[1] Jayaraman A, Christensen A, Moser VA, Vest RS, et al. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014 Apr;155(4):1398-406.

[2] LoRusso P, Hamilton E, Ma C, Vidula N, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022 Jan;22(1):67-77.

[3] Padappayil RP, Chandini Arjun A, Vivar Acosta J, Ghali W, et al. Acute Myocarditis From the Use of Selective Androgen Receptor Modulator (SARM) RAD-140 (Testolone). Cureus. 2022 Jan 27;14(1):e21663.

[4] Puskas J, Guda T, Niccoli S, Rathbone CR, et al. Preclinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density. Physiol Rep. 2025 Jul;13(14):e70463.

[5] Leung K, Yaramada P, Goyal P, Cai CX, Thung I, Hammami MB. RAD-140 Drug-Induced Liver Injury. Ochsner J. 2022 Winter;22(4):361-365.

[6] Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, et al. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017 Nov 28;318(20):2004-2010.

Molecular Formula: C₂₀H₁₆ClN₅O₂
Molecular Weight: 393.83 g/mol

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Romania Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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